Associate Scientist, Gene Editing and iPSC Engineering

We are seeking a highly skilled, passionate, and motivated scientist to join our diabetes team. This position will play a key lab-based role in advancing iPSC stem cell engineering and will contribute to the development of the next generation of islet cell therapies. Successful candidates will have experience with gene editing, molecular biology techniques, assay development, and human iPSC cell culture, differentiation, and banking.Key Responsibilities:Enabling and advancing iPSC gene editing, cell line development, and evaluation of differentiated cells.Routine iPSC cell culture, passaging, and media making.Optimize workflows for iPSC CRISPR based gene-editing, gRNA screening, and delivery.Optimize and perform assays for on-/off-target analysis via PCR and NGS workflows.Generate clonal gene edited iPSC lines and characterize via flow cytometry, ddPCR, dPCR and qPCR.Culture and execute routine directed differentiation of human iPSCs to pancreatic islets performing drug substance assessments such as cell counts, viability, and metabolite assessments.Assist scientists in the team to evaluate and design mitigation strategies to ensure genomic stability of the iPSC lines and drug substance.Collaborate cross-functionally to support transfer of R&D assays to GMP.Maintain accurate and detailed records of all experiments, synthesize results, prepare reports, and present in meetings. Contribute to SOP development.Work seamlessly in executing workplans and meeting deadlines.